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Bottom: Oil red O staining showing changes in neutral lipid storage with different forms of endocrine resistance. https://www.sartoriuslab.com/current-projects/pr-rar-crosstalk-breast-cancer monthly 0.5 2022-06-23 https://images.squarespace-cdn.com/content/v1/6262ef4bda697b5a84efeabd/41e7707d-2109-4885-b3d2-7ad5e3ee422e/heterogeneity+pics.jpg Current Projects - Regulation of ER+ breast cancer heterogeneity and cancer stem cells ER and PR heterogeneity with the basal cell marker CK5 in PDX and T47D cells. sc ATAC-seq of T47D cells with progestin (P) treatment or estrogen withdrawal (EWD) https://www.sartoriuslab.com/current-projects/project-four-6wayz monthly 0.5 2022-06-23 https://images.squarespace-cdn.com/content/v1/6262ef4bda697b5a84efeabd/ad288dd4-e7fe-4510-b30f-2a05af8a0d80/Mets2.jpg Current Projects - Mechanisms of ER+ breast cancer metastasis Left: GFP labeled metastases to bone (femur) and brain and CTCs from ER+ breast cancer PDX. Right: TSNE plot of sc RNA-seq of primary tumor, and bone and brain metastatic cells. https://www.sartoriuslab.com/current-projects/hormonal-regulation-cell-metabolism monthly 0.5 2022-06-27 https://images.squarespace-cdn.com/content/v1/6262ef4bda697b5a84efeabd/86197303-b7b1-4979-873b-740e9d3e7f9a/Cell+lines_ICC_unflat+copy.jpg Current Projects - HR+ breast cancer PDX and PDCL ER and PR expression in several UCD PDX and PDCL https://www.sartoriuslab.com/current-projects/pr-regulation-trna-biology monthly 0.5 2022-06-08 https://images.squarespace-cdn.com/content/v1/6262ef4bda697b5a84efeabd/8c90653c-8572-4590-b382-b2c97b9b9df4/PolIII+figure.jpg Current Projects - Nuclear receptor regulation of RNA polymerase III Schematic of proposed PR association with the Pol III transcription complex. https://www.sartoriuslab.com/current-projects/bcatenin-ck5-csc monthly 0.5 2022-06-10 https://images.squarespace-cdn.com/content/v1/6262ef4bda697b5a84efeabd/1650669695840-0OPZGQSFNB9HZ7QMK45X/bcat.png Current Projects - Cytokeratin regulation of breast cancer cells Immunofluorescent staining showing loss of β-catenin or E-cadherin (green) at the cell membrane in breast cancer cells expressing an empty vector or CK5 (red).